Story (Credit Wikipedia):
Set a few months after the events of the film, Peter Parker and Gwen Stacy sneak into the restricted areas of Oscorp after hours, where Gwen reveals her suspicions that they may be continuing the cross-species experiments of Dr. Curt Connors, who had become the monstrous Lizard. They are caught by Alistair Smythe, the new Oscorp director, who confirms Gwen’s suspicions, although the cross-species carry a powerful virus and are to be disposed. However, the cross-species all react to the presence of Peter, a cross-species himself, and break out, infecting all of the scientists, including Smythe and Gwen, in the process. Smythe unleashes his security robots, which are programmed to defend them from cross-species. Peter quickly dons his Spider-Man suit and gets the infected to quarantine, fighting off the robots in the process, but is unable to stop the cross-species and the virus from escaping into the city.
Spider-Man goes to the Beloit Psychiatric Hospital, and seeks the help of the incarcerated Connors to develop a cure for the virus. Connors relents, but only if he is returned to the asylum when the crisis is resolved. They set up a laboratory at the apartment of Aunt May‘s friend Stan, and begin development of an antidote, while keeping in close contact with Gwen and Smythe via webcam. At the same time, Smythe is developing his own “cure” which involves nanobots destroying the host from the inside out. Spider-Man also forms an alliance with Whitney Chang, an investigative reporter who believes Oscorp’s facelift operation is a scam, in unveiling the suspicious activities of Oscorp.
Connors manages to create an antidote, which Spider-Man delivers to Gwen, however a skeptical Smythe decides to test it on himself; he unexpectedly loses the use of his legsas well as his sanity, and, in a fit of rage, programs his robots to eliminate Spider-Man. Returning to Connors after narrowly escaping the robots, a heavily injured Spider-Man berates Connors about the antidote’s failure before passing out from his injuries. Since Spider-Man retains his humanity despite being a cross-species, Connors uses Spider-Man’s blood to create a more accurate antidote. Spider-Man travels to Oscorp and manages to cure Gwen and the other scientists with the antidote. Meanwhile, the CDC quarantines the city with the advancement of the virus.
Smythe, having been fired from Oscorp, somehow discovers both Spider-Man’s secret identity and the location of their apartment. He subsequently kidnaps Connors and dares Spider-Man to come save him. Spider-Man breaks into the Oscorp robotics facility and manages to free Connors, only to be subdued by the robots. While Connors escapes and returns to his old lab in the sewers, Smythe restrains Spider-Man and injects him with his completed nanobot serum, which strips him of his powers. With his powers gone and health fading fast, Peter narrowly escapes from the facility as Smythe activates his S-03 robot to enact his plan to spread his nanobot serum all over the city. As a result of the war between the infected and Smythe’s robots, the city is in chaos. Spider-Man manages to travel to Connors’ sewer lab to reunite with Connors and Gwen, but he passes out with the nanobots slowly killing him. Deciding that there is no other way to stop Smythe’s robots, Connors transforms himself as the Lizard. Gwen manages to revive Spider-Man with an AED, and a de-powered Spider-Man manages to make his way to the S-03 with Whitney Chang’s help. Recalling his experience with the AED, he enters the robot and electrocutes himself to destroy the nanobots in his body. With the help of the Lizard, he manages to defeat Smythe and destroy the S-03, however Connors succumbs to the Lizard’s consciousness and flees to the sewers. Regaining his sanity, a remorseful Smythe is arrested, while Spider-Man searches for the Lizard. As Gwen reprograms a robot to administer the cure, Spider-Man manages to subdue the Lizard and cure him, eventually returning Connors to the asylum.
With the cure discovered, the virus has been eliminated, and Spider-Man is revered by the city as a hero. Peter and Gwen realize through one of Chang’s news reports that Smythe has escaped custody, but they decide to deal with it later.
Free Roam: New York. Tour Times Square, and several other buildings. However, there is no Empire State Building, and often a building is repeated many times. Unlike The Amazing Spider-Man 2, there is no buildings in construction, Empire State Building, or Brooklyn bridge.
My Free Roam Rating: 3.5/5
Graphics: The graphics are awesome!! There’s detail on the citizens’ faces! You can also see the grass on the ground!!
My Graphics Rating: 4.5/5
Car Chases: Quite a few!
Side Quests: Lots of them!! They include Petty Crimes, Xtreme Challenges, Car Chases, Police Deadlocks,+ more!!
Hard Disc Space: 5mb
My Overall Rating: 
PlayStation 3 games 